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Author: Speck, Ulrich

Added by: sketch

Added Date: 2015-12-30

Language: eng

Subjects: Medicine, Medical radiology, Medicine, Medical radiology

Publishers: Berlin, Heidelberg : Springer Berlin Heidelberg

Collections: folkscanomy miscellaneous, folkscanomy, additional collections

ISBN Number: 9783642859953, 364285995X

Pages Count: 600

PPI Count: 600

PDF Count: 1

Total Size: 132.97 MB

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Description

Contrast Media: Overview, Use and Pharmaceutical Aspects
Author: Professor Dr. Ulrich Speck
Published by Springer Berlin Heidelberg
ISBN: 978-3-540-65712-5
DOI: 10.1007/978-3-642-85995-3

Table of Contents:

  • Introduction
  • General Principles of X-ray Contrast Media
  • Structure and Properties of X-ray Contrast Media
  • Physicochemical Properties of Water-Soluble Contrast Media
  • Possible Uses of X-ray Contrast Media
  • Pharmaceutical Product Quality
  • Interactions
  • Risks of Contrast Media Use
  • Drugs and Measures for the Treatment of a Contrast Medium Reaction
  • Special Characteristics of the Contrast Media for Magnetic Resonance Imaging
  • Special Characteristics of the Contrast Media for Ultrasound
  • Further Development of Contrast Media

Contrast media in diagnostic imaging -- General principles of X-ray contrast media -- Structure and properties of X-ray contrast media -- Barium sulfate -- Water-soluble contrast media -- Physicochemical properties of water-soluble contrast media -- Water solubility -- Viscosity/Temperature -- Osmolality -- Hydrophilia/Lipophilia -- Electrical charge -- Others -- Possible uses of X-ray contrast media -- Principles of opacification -- Pharmaceutical product quality -- Practical information at a glance -- Purity of the active ingredient, by- and degradation products -- Formulations -- Additives -- Microbiological quality of the finished product -- Preservation of product quality in hospitals and practices -- Interactions -- Influence on laboratory tests -- Interactions with medicines -- Interaction of contrast media with additives and during interventional procedures -- Effects on blood coagulation -- Risks of contrast media use -- Ionic contrast media -- Nonionic contrast media -- Delayed reactions -- Causes of contrast media reactions -- General reactions (anaphylactoid reactions) -- Prophylaxis of general reactions -- Dose-dependent side effects -- Prophylaxis and therapy of severe iodine-induced hyperthyroidism -- Renal damage -- Pregnant patients -- Breast-feeding mothers -- Pheochromocytoma -- Sickle-cell anemia -- Drugs and measures for the treatment of a contrast medium reaction -- Special characteristics of the contrast media for magnetic resonance imaging -- Mechanisms of action -- Structure and pharmacological characteristics -- Pharmaceutical product quality -- Administration -- Contrast media for the gastrointestinal tract -- Contrast media for other body cavities -- Special handling characteristics -- Influence on laboratory tests -- Interaction with medications -- Risks related to Magnevist use -- Comparison with X-ray contrast media -- Special characteristics of the contrast media for ultrasound -- Contrast media and their mechanisms of action -- Composition and preparation before use -- Application -- Pharmaceutical product quality -- Influence on laboratory tests -- Interaction with medications -- Risks related to the use of echo contrast media -- Further development of contrast media -- References -- Commercial brands and their iodine content (g)
Contrast media in diagnostic imaging 8 Visualization of functions 8 - Morphology 9 - General principles of X-ray contrast media 10 13 Structure and properties of X-ray contrast media Barium sulfate 13 Water-soluble contrast media 14 Chemical structure, biological behavior and use 14 - Conventional, highly hypertonic contrast media 15 - Low-osmolar contrast media, especially non ionic substances 15 - Nonionic contrast media 16 Osmolality and side effects caused by hypertonicity 18 Ionic contrast media 20 21 Contrast media for intravenous cholegraphy - Contrast media for oral cholegraphy 22 - Cations 23 - Synthesis of water-soluble contrast media 25 - Physicochemical properties of water-soluble contrast media 26 26 Water solubility ViscositylTemperature 26 27 Osmolality Hydrophilia/Lipophilia 28 Electrical charge 29 29 Others Possible uses of X-ray contrast media 31 Principles of opacification 31 Pharmaceutical product quality 37 37 Practical information at a glance Purity of the active ingredient, by-and degradation products 38 Formulations 40 5 Additives 40 Microbiological quality of the finished product 42 - Production under controlled environmental conditions 42 - Production process 44 - Sterile filtration, ultrafiltration and sterilization 46 - Sterility test 47 - Test for pyrogens 47 Preservation of product quality in hospitals and practices 48 - Stability in long-term storage and at different temperatures 49 - Sensitivity to irradiation and light; white glass, brown glass, UV-protective foil 50 - Tests for contamination with particles 52 - Risks of microbial contamination 54 - Transferring the contrast medium to sterile containers, disposable syringes, automatic injectors 55

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