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The possibility of neuroleptic malignant syndrome should be kept in mind in patients on antipsychotic medication with fever extrapyramidal symptoms disturbances in the function of the autonomic nervous system disturbances of consciousnessleucocytosis or an increase in the plasma creatine kinase (CK) concentration as an additional laboratory finding. NMS may occur with any type of antipsychotic drug and also with metoclopramide.Other disorders causing clouding of consciousness, confusion and elevation of body temperature should be excluded.Restarting antipsychotic medication after NMS requires the opinion of a specialist.