Calcium Channel Blockers [electronic resource]

Calcium Channel Blockers
Author: Théophile Godfraind
Published by Birkhäuser Basel
ISBN: 978-3-0348-9599-6
DOI: 10.1007/978-3-0348-7859-3

Table of Contents:

• Historical perspective: from early steps on calcium research to the identification of calcium antagonist prototypes and of the signaling functions of Ca2+
• Calcium channel blockers and calcium channels
• The action of calcium antagonists on Ca2+ movements in isolated vessels
• The tissue selectivity of calcium antagonists
• Acute haemodynamic effects of calcium channel blockers
• Calcium channels and regulation of vascular tone in hypertension
• Long-term effects of calcium antagonists
• Blood pressure-independent effects of calcium antagonists
• From early clinical studies to randomized controlled clinical trials
• Beyond the cardiovascular system

Preface -- Acknowledgements -- Historical perspective: from early steps on calcium research to the identification of calcium antagonist prototypes and of the signaling functions of Ca2+ -- Calcium channel blockers and calcium channels -- The action of calcium antagonists on Ca2+ movements in isolated vessels -- The tissue selectivity of calcium antagonists -- Acute haemodynamic effects of calcium channel blockers -- Calcium channels and regulation of vascular tone in hypertension -- Long-term effects of calcium antagonists -- Blood-pressure independent effects of calcium antagonists -- From early clinical studies to randomized controlled clinical trials -- Beyond the cardiovascular system -- Index
The main effect of calcium channel blockers is the blockade of calcium entry into cells through voltage operated calcium channels. This volume gives a comprehensive overview of the different classes of CCBs and their various effects. It covers historical development, pharmacology, clinical aspects, and perspectives. All chapters are written by Prof. T. Godfraind, a world leading expert in the field