Cytokines and Joint Injury [electronic resource]

Cytokines and Joint Injury
Author: Prof. Dr. Wim B. van den Berg, Prof. Dr. Pierre Miossec
Published by Birkhäuser Basel
ISBN: 978-3-0348-9609-2
DOI: 10.1007/978-3-0348-7883-8

Table of Contents:

• The role of tumour necrosis factor in rheumatoid arthritis
• The IL-1 family: The role of IL-1 and IL-18 in inflammation
• Targeted IL-1 inhibition
• Is IL-6 a therapeutic target?
• The clinical use of anti-cytokine therapy in rheumatic diseases
• Innate response cytokines in inflammatory synovitis: interleukin-15 and interleukin-18
• IL-17 as a contributor to inflammation and destruction in rheumatoid arthritis
• Cell-cell contact in chronic inflammation: the importance to cytokine regulation in tissue destruction and repair
• The role of proteinases in joint tissue destruction
• Receptor activator of nuclear factor кB ligand (RANKL) versus osteoprotegerin (OPG): the yin and yang of joint integrity
• Cytokine regulation of bone destruction

This topical insight in the role of cytokines in joint inflammation and joint destruction is important for a better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of well-known and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Special attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay as well as mechanisms of cartilage destruction and bone erosion. New information on the novel cytokines IL-15, IL-17 and IL-18 and their position in the complex cytokine interplay is provided, in addition to an outline of the role of established cytokines, such as TNF, IL-1 and IL-6. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles as central players in joint erosion are highlighted. This volume gives a complete and balanced view on pivotal cytokines and joint pathology for the biomedical and clinical researcher
The role of tumour necrosis factor in rheumatoid arthritis -- The IL-1 family: the role of IL-1 and IL-18 in inflammation -- Targeted IL-1 inhibition -- Is IL-6 a therapeutic target? -- The clinical use of anti-cytokine therapy in rheumatic diseases -- Innate response cytokines in inflammatory synovitis: interleukin-15 and interleukin-18 -- IL-17 as a contributor to inflammation and destruction in rheumatoid arthritis -- Cell-cell contact in chronic inflammation: the importance to cytokine regulation in tissue destruction and repair -- The role of proteinases in joint tissue destruction -- Receptor activator of nuclear factor KB ligand (RANKL) versus osteoprotegerin (OPG): the yin and yang of joint integrity -- Cytokine regulation of bone destruction