Advanced methods of pharmacokinetic and pharmacodynamic systems analysis. [electronic resource] | Biomedical Simulations Resource Workshop on Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis (2003 : Marina del Rey, Calif.), D'Argenio, David Z

Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis Volume 3
Author: David Z. D’Argenio
Published by Springer US
ISBN: 978-1-4020-7804-0
DOI: 10.1007/b105246

Table of Contents:

• Physiological Modeling of the Small Intestine in Drug Absorption
• Intracellular Metabolism of Lamivudine
• Mechanism-Based Pharmacodynamic Modeling for Prediction of Exposure Response
• Mechanism-Based PK/PD Modeling of Digoxin: Role of Receptor Heterogeneity and Postrecepotor Events
• Pharmacodynamics and Pharmacogenomics of Corticosteroids: Microarray Studies
• Bayesian Inference in Physiologically-based Pharmacokinetic Modeling: Application to Aniticancer Drug Development
• Monte Carlo Parametric Expectation Maximization (MC-PEM) Method for Analyzing Population Pharmacokinetic/Pharmacodynamic Data
• Applications of Markov Chain Monte Carlo Methods to Inverse Problems in PK/PD
• Regenerative Markov Chain Monte Carlo Methods for Pharmacokinetic/Pharmacodynamic Estimation
• Vizstruct: A Multidimensional Visualization Algorithm for Gene Expression
• Modeling and Simulation of Effects of Adherence, Pharmacokinetic, and Pharmacodynamic Characteristics in Development of Resistance to HIV Regimens in Treatment-Naive Patients
• Mechanistic PK/PD Modeling of Antiretroviral Therapies in AIDS Clinical Trials
• Dose Individualization for High-dose anti-cancer Chemotherapy
• Toward Model-Based Chemotherapy Treatment Design
• Control of Uncertain Pharmacodynamic Systems

Proceedings of the 10th workshop on advanced methods of PK/PD systems analysis held in, Marina del Rey, California on June 16 and 17, 2003
Includes bibliographical references and index
Preliminaries; CONTENTS; Preface; Physiological Modeling of the Small Intestine in Drug Absorption; Intracellular Metabolism of Lamivudine; Mechanism-Based Pharmacodynamic Modeling for Prediction; Mechanism-Based PK/PD Modeling of Digoxin: Role of Receptor Heterogeneity and Postrecepotor Events; Pharmacodynamics and Pharmacogenomics of Corticosteroids: Microarray Studies; Bayesian Inference in Physiologically-Based Pharmacokinetic Modeling: Application to Anticancer Drug Development
Advanced Methods of Pharmacokinetic and Pharmocodynamic Systems Analysis Volume 3 is vital to professionals and academicians working in drug development and bioengineering. Both basic and clinical scientists will benefit from this work. This book contains chapters by leading researchers in pharmacokinetic/pharmacodynamic modeling and will be of interest to anyone involved with the application of pharmacokinetic and pharmacodynamics to drug development. The use of mathematical modeling and associated computational methods is central to the study of the absorption, distribution and elimination o