Microvascular Perfusion Abnormalities of the Thalamus in Painful but Not Painless Diabetic Polyneuropathy: A c
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Author: Selvarajah, Dinesh, Wilkinson, Iain D., Gandhi, Rajiv, Griffiths, Paul D., Tesfaye, Solomon
Added by: jake
Added Date: 2014-10-24
Language: eng
ISSN Number: 0149-5992 (Print) 1935-5548 (Electronic)
Pages Count: 600
PPI Count: 600
PDF Count: 1
Total Size: 6.04 MB
PDF Size: 532.08 KB
Extensions: djvu, gif, pdf, gz, zip, torrent
Volume: 34
Contributor: American Diabetes Association
Downloads: 68
Views: 118
Total Files: 14
Media Type: texts
Total Files: 5
Description
This article is from Diabetes Care, volume 34.
Abstract
OBJECTIVE: The pathogenesis of painful diabetic neuropathy (DN) remains undetermined, with both central and peripheral mechanisms implicated. This study investigates whether thalamic perfusion abnormalities occur in painful DN. RESEARCH DESIGN AND METHODS: Eighteen subjects with type 1 diabetes (no DN = 6, painful DN = 5, painless DN = 7) and six healthy volunteers (HV) were recruited. Microvascular perfusion characteristics (relative cerebral blood volume [rCBV], flow [rCBF], and transit time [ttFM]) of the thalamus and caudate nucleus were assessed using magnetic resonance perfusion imaging. The caudate nucleus was chosen to serve as an in vivo control region. RESULTS: Subjects with painful DN had significantly greater thalamic rCBV (means [SD]; painful DN, 228.7 [19.5]; no DN, 202.3 [25.8]; painless DN, 216.5 [65.5]; HV, 181.9 [51.7]; P = 0.04) and the longest ttFM(s) (painful DN, 38.4 [3.6]; no DN, 35.3 [13.2]; painless DN, 35.9 [13.7]; HV, 33.7 [14.9]; P = 0.07). There was no significant difference in markers of caudate nucleus perfusion. CONCLUSIONS: Painful DN is associated with increased thalamic vascularity. This may provide an important clue to the pathogenesis of pain in DN.You May Also Like
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